Europe is in a time of dramatic change, war, economic crisis, climate change, migration, digitalisation, pandemics, ageing and demographic change, place increasing stress and pressure on our societies to adapt to fast-changing situations. Particular vulnerable groups in the general population are especially at risk of being disadvantaged by dramatic societal change, of experiencing particular stressors, and of suffering (further) negative impacts on their wellbeing, including mental health. Building on the MENTBEST members’ experience on community-based interventions to reduce depression and suicidal behaviour and the intervention framework (EAAD 4-Level-Intervention), the MENTBEST consortium will (a) characterise the scale of the change-related mental health challenges; (b) work with patients, healthcare and other stakeholders to identify interventions and tools that can best build resilience and maintain mental health; (c) combine these interventions with an adapted and broadened EAAD 4 Level Intervention into a comprehensive community based intervention (COMBINA).